Wellcome Open Research logo.

Today sees the launch of Wellcome Open Research, a new publication platform for Wellcome Trust funded researchers. A set of articles released to coincide with the launch includes ‘Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice‘, a publication by the DMDD Programme. It explores the results of systematic efforts by the consortium to image and phenotype embryos from embryonic-lethal knockout mouse lines.


Papers submitted to WOR are published immediately as preprints, following a series of objective checks. They are then subject to a process of open peer review. WOR requires all supporting data to be made available, enabling other researchers to analyse and replicate published studies. By using services developed by the publisher F1000Research, research outputs can be made available faster and in ways that support reproducibility and transparency.

DMDD’s Tim Mohun on the reasons the team chose to publish in WOR:

“For us, the timing of the launch was perfect. We had reached a bit of a milestone in the DMDD project, having analysed enough different embryonic lethal genes that we could begin to consider the dataset as a whole and draw some initial conclusions. We wanted to share our findings with the research community as quickly as possible because we think the conclusions are interesting, important and, in part, puzzling.

Lots of research never sees the light of day. We only ever see the choice results and final conclusions in conventional scientific publications, but rarely all the accumulated data on which those studies rest. For screening studies like ours which are necessarily limited in depth but wide in scope, publications like Wellcome Open Research give the opportunity to make our data available for other scientists to use, hopefully helping to advance their work and avoiding duplication of effort”.

The DMDD paper ‘Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice‘ is currently undergoing peer review and this process can be followed online.

Read a longer interview with Tim Mohun and Jim Smith on the WOR blog.