HREM


JOIN OUR HREM AND PHENOTYPING WORKSHOP

Generation and interpretation of HREM data from normal and mutant E14.5 mouse embryos in the DMDD programme   20 – 22 October 2017 The Medical University of Vienna   Deciphering the Mechanisms of Developmental Disorders (DMDD) is a large-scale imaging and phenotyping programme for genetically modified mouse embryos. For embryos […]

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DMDD WEBSITE ENHANCEMENTS

Following user testing of the DMDD website at the BSCB/BSDB meeting earlier this year, we’ve been working behind the scenes on some enhancements to our site. The changes went live today, and here’s a rundown of what’s new. HOMEPAGE Perhaps the first thing you might notice is our updated homepage. […]


HREM IMAGING REVEALS DETAILS OF ABNORMAL EMBRYO DEVELOPMENT

High Resolution Episcopic Microscopy (HREM) is a technique that allows embryos to be imaged in unprecedented 3D detail. It’s the main imaging method used by the DMDD programme – we use it to identify a wide range of developmental abnormalities that result from mouse gene knockouts. The detail revealed by […]

Brd2 embryo.

Brd2 embryo.

NEW DMDD YOUTUBE CHANNEL

This week sees the launch of the DMDD YouTube channel. We’ve added videos that explore different aspects of our embryonic-lethal mouse data, providing a new way to visualise phenotypes that we’ve observed in our knockout lines. For example, this video compares HREM data from a Psph mutant embryo with its wild-type […]


DATA RELEASE – AUGUST 2016

New embryonic-lethal knockout mouse lines are now available on the DMDD database. If you haven’t previously taken a look at our data (or even if you have) now would be a good time to explore our website.  We’ve added new embryo phenotype data and HREM images for many knockout lines, […]

An Adamts3 embryo displays bifid ureter and subcutaneous edema.