Discussion


7 MOUSE PHENOTYPE RESOURCES

If you are interested in mouse phenotypes, you’ll have noticed that there are a wealth of resources available. Here’s our round-up of some of the best databases out there. Did we miss your favourite? Let us know by contacting us on Twitter @dmdduk. Mouse Genome Informatics           […]


EDEMA – A SIGN OF UNDERLYING DEVELOPMENTAL DEFECTS

In around 30% of the knockout lines studied by DMDD, the embryos have edema – swelling due to fluid trapped in the embryo’s tissues. Most of us have experienced edema at some point, after a bee sting, an infection or perhaps from hitting your thumb with a hammer. One reason that […]


CAN WE IDENTIFY MORE GENES WITH LINKS TO MISCARRIAGE?

Around 1 in 4 pregnancies ends in miscarriage, but in many cases a definite cause cannot be found. It’s an all-too-common situation that is heart breaking for parents, and incredibly frustrating for the clinicians involved. Miscarriage can happen for many reasons, including infection and hormonal imbalances. But around half of […]


TEA, DINNER OR SUPPER?

Like most big biomedical research projects, DMDD is gathering huge amounts of data. The latest count is more than 5 million images of developing embryos, and thousands of abnormalities (or phenotypes) that have been identified within them. So we need to be organised. All that time spent collecting and analysing […]


HOW MICE ARE KEY TO UNDERSTANDING GENETIC HEART CONDITIONS

Nearly 1 in every 100 babies is born with a heart defect. These are the most common type of birth defect and can range from simple, symptomless cases to life-threatening conditions that require treatment within hours of birth. Environmental influences such as excessive alcohol consumption or exposure to other toxins […]


THE ZIKA VIRUS AND DMDD

The Zika virus has raised global awareness of birth defects more than at any time in the last 50 years [1]. A recent Nature Editorial explores the opportunities this presents to increase support for vaccination programmes, compulsory fortification of food staples and investment in population-scale databases to mine information on […]

Mosquito

WHAT IS NORMAL?

At the DMDD one of our projects is to measure the amount of variation in wild-type embryos. But this led us to ask the question – what is normal? We asked some leading scientists for their opinions and found that it can be quite hard to define. What does normal […]