Yearly Archives: 2017


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JOIN OUR HREM AND PHENOTYPING WORKSHOP

Generation and interpretation of HREM data from normal and mutant E14.5 mouse embryos in the DMDD programme   20 – 22 October 2017 The Medical University of Vienna   Deciphering the Mechanisms of Developmental Disorders (DMDD) is a large-scale imaging and phenotyping programme for genetically modified mouse embryos. For embryos […]


WHAT DOES NORMAL HEART DEVELOPMENT REALLY LOOK LIKE?

Every developing heart is subtly different. Hearts and their blood vessels don’t always grow at the same rate, to exactly the same size or precise shape, and this can complicate things if we want to identify an abnormality. To be sure if any feature of a heart is abnormal, first we […]


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9.5 MILLION EMBRYO IMAGES NOW AVAILABLE

A new set of DMDD embryo and placenta data has been released today, taking our total dataset to 9.5 million images of around 1300 embryos. Phenotypes are available for embryos from 73 different knockout lines, and we have phenotyped the placentas from 124 lines. We have also added data on […]


EDEMA – A SIGN OF UNDERLYING DEVELOPMENTAL DEFECTS

In around 30% of the knockout lines studied by DMDD, the embryos have edema – swelling due to fluid trapped in the embryo’s tissues. Most of us have experienced edema at some point, after a bee sting, an infection or perhaps from hitting your thumb with a hammer. One reason that […]


MEET US AT ISDB 2017

  The International Society for Developmental Biologists 2017 meeting is taking place in Singapore from 18 – 22 June, and we’re currently putting the finishing touches to our exhibit. On stand 11, Emily and Chris will be able to show you detailed phenotype data for embryonic lethal knockout mouse lines, […]


CAN WE IDENTIFY MORE GENES WITH LINKS TO MISCARRIAGE?

Around 1 in 4 pregnancies ends in miscarriage, but in many cases a definite cause cannot be found. It’s an all-too-common situation that is heart breaking for parents, and incredibly frustrating for the clinicians involved. Miscarriage can happen for many reasons, including infection and hormonal imbalances. But around half of […]


FIND DMDD PHENOTYPE DATA IN THE MGI DATABASE

DMDD embryo phenotype data is now available in the Mouse Genome Informatics (MGI) database, complimenting the existing morphological phenotype data that is held there. To date we have contributed detailed phenotypes for 63 knockout lines, and will continue to provide additional data as it becomes available. Each allele overview page shows the high […]


TEA, DINNER OR SUPPER?

Like most big biomedical research projects, DMDD is gathering huge amounts of data. The latest count is more than 5 million images of developing embryos, and thousands of abnormalities (or phenotypes) that have been identified within them. So we need to be organised. All that time spent collecting and analysing […]