Yearly Archives: 2016


MEET THE DMDD TEAM – MYRIAM HEMBERGER

In a series of interviews we’re hearing from members of the DMDD programme. Who are they? What inspires them? And what do they hope that DMDD will achieve? This month we speak to Myriam Hemberger, who leads the team’s analysis of placentas from embryonic lethal knockout mouse lines. What has […]


NEW EMBRYO PHENOTYPE DATA AVAILABLE

New image and phenotype data for embryos and placentas from embryonic lethal knockout mouse lines has been made available on the DMDD website today. The knockout data includes the ciliary gene Rpgrip1l as well as Atg16l1, a gene encoding a protein that forms part of a larger complex needed for […]


DMDD WEBSITE ENHANCEMENTS

Following user testing of the DMDD website at the BSCB/BSDB meeting earlier this year, we’ve been working behind the scenes on some enhancements to our site. The changes went live today, and here’s a rundown of what’s new. HOMEPAGE Perhaps the first thing you might notice is our updated homepage. […]


Wellcome Open Research logo.

WELLCOME OPEN RESEARCH LAUNCH INCLUDES DMDD EMBRYO PHENOTYPING PAPER

Today sees the launch of Wellcome Open Research, a new publication platform for Wellcome Trust funded researchers. A set of articles released to coincide with the launch includes ‘Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice‘, a publication by the DMDD Programme. It explores the results of systematic efforts by the […]


MEET THE DMDD TEAM – LIZ ROBERTSON

  In a new series of interviews we’ll hear from members of the DMDD team. Who are they? What inspires them? And what do they hope that the DMDD programme will achieve? We kick things off with joint grant-holder Liz Robertson.   What has been your main area of research […]

Photograph of Professor Elizabeth Robertson

Brd2 embryo.

HREM IMAGING REVEALS DETAILS OF ABNORMAL EMBRYO DEVELOPMENT

High Resolution Episcopic Microscopy (HREM) is a technique that allows embryos to be imaged in unprecedented 3D detail. It’s the main imaging method used by the DMDD programme – we use it to identify a wide range of developmental abnormalities that result from mouse gene knockouts. The detail revealed by […]


NEW PHENOTYPE SCREEN EXAMINES CAUSES OF NEONATAL DEATH

Around a third of targeted gene knockouts in mice are embryonic-lethal. But not all deaths occur during gestation – a significant number of gene knockouts result in death at or shortly after the time of birth. Mice from these knockout lines provide a valuable animal model of human neonatal death […]

Nesting wild-type pups.

A NEW BASELINE RNA EXPRESSION PROFILE FOR MOUSE EMBRYOS

Knowing the ‘normal’ expression of genes during embryo development is key to understanding the differences that occur due to genetic mutations. As part of work to understand the underlying transcriptional processes in developing embryos from knockout mouse lines, DMDD has now released a gene expression profile for wild-type mouse embryos […]


3 NEW RESULTS FROM KNOCKOUT MOUSE SCREENS

Around a third of mammalian genes are essential for life, and the recent Nature paper from the IMPC  ‘High-throughput discovery of novel developmental phenotypes‘ [1] describes some achievements from sytematic study of these genes in knockout mice. Screens like those of the IMPC and DMDD are vital to understand gene […]

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